Why Do Pill Bottles Have Cotton Balls in Them?

Author Nicole Villeneuve
November 3, 2026

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When you buy a bottle of over-the-counter pain relievers, you might expect to open it up and have to pull out a wad of cotton that’s stuffed inside at the top. It’s a curious bit of packaging, considering you didn’t order a side of craft supplies with your medicine. So why do you find a puff of white cotton in your pill bottle?

When pharmaceutical companies began putting cotton in pill bottles, it served a practical purpose. While that eventually became obsolete, the cotton itself proved hard to get rid of. 

Credit: © Science & Society Picture Library/Getty Images

It Started With Aspirin Bottles

The practice began with Bayer, the German pharmaceutical company behind aspirin. In the early 20th century, Bayer began using cotton wads in its aspirin bottles not to keep the medicine fresh, but to solve a more straightforward problem.

Aspirin tablets, made with acetylsalicylic acid as their active ingredient, could be quite fragile, breaking or crumbling as they rattled around inside the containers during transport. The cotton filled the empty space above the pills, helping keep them from moving around and breaking apart before they reached the customer.